Chronic delta hepatitis: from discovery to new treatments
نویسندگان
چکیده
Introduction. Hepatitis delta virus (HDV) is a small, defective RNA that related more to plant viroids than other human pathogens. 
 Material and methods. Nearly 50 research articles from various sources were reviewed comprehensive analysis was done regarding parameters concerning HDV. Articles published over period of 30 years selected based on their experimental statistical relevance This review gives brief insight into epidemiology, genetics, clinical evolution treatment chronic hepatitis delta.
 Results. Chronic remains major cause morbidity in Eastern European countries the Mediterranean region. At same time, there resurgence HBV HDV infection young people (under age 50) Western Europe, as consequence intra-familial sexual mode acquisition among immigrants region former Soviet Union, Africa high burdened regions Asia South America. Prevalence IVDU found be higher especially western european low prevalence. viral dynamic, progressive process. A direct cytopathic pattern liver tissue damage also observed, presence genotype 3. D reported progress cirrhosis hepatocellular cancer, this trend greater level viremia at time presentation.
 Conclusions. Flaws screening on-time diagnosis still remain due insufficient data available. While not classified carcinogen by IARC, our ends up support notion increases chances fastens pathogenic processes leading HCC.
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ژورنال
عنوان ژورنال: One Health & Risk Management
سال: 2021
ISSN: ['2587-3458', '2587-3466']
DOI: https://doi.org/10.38045/ohrm.2021.2.03